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Extrinsic factors responsible for skin aging mainly include:

  1. Genetic factors

  2. Environmental factors

  3. Hormonal changes

  4. Immune system function

The correct answer is: Environmental factors

Environmental factors such as sun exposure, pollution, and smoking can all contribute to skin aging. Genetic factors, although also play a role in skin aging, cannot be controlled or prevented. Hormonal changes and immune system function are also important for overall health, but do not directly affect the aging of skin. Therefore, B is the most appropriate answer.